UniProt Protein Function: | TICAM1: an adaptor protein involved in innate immunity against invading pathogens. Associates with TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Interacts with the TIR domain of TLR3. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3. Interacts with TRAFD1. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Apoptosis Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: endosome membrane; cytosol Molecular Function:protein binding; signal transducer activity; protein kinase binding Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric oxide biosynthetic process; positive regulation of protein binding; regulation of protein homodimerization activity; MyD88-independent toll-like receptor signaling pathway; positive regulation of interleukin-6 production; toll-like receptor 3 signaling pathway; positive regulation of tumor necrosis factor production; positive regulation of natural killer cell activation; activation of NF-kappaB transcription factor; positive regulation of chemokine biosynthetic process; response to exogenous dsRNA; positive regulation of protein ubiquitination; macrophage activation during immune response; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; positive regulation of B cell proliferation; lipopolysaccharide-mediated signaling pathway; innate immune response; inflammatory response; toll-like receptor 4 signaling pathway; defense response to virus Disease: Herpes Simplex Encephalitis, Susceptibility To, 4 |
NCBI Summary: | This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012] |
UniProt Code: | Q8IUC6 |
NCBI GenInfo Identifier: | 74727957 |
NCBI Gene ID: | 148022 |
NCBI Accession: | Q8IUC6.1 |
UniProt Related Accession: | Q8IUC6 |
Molecular Weight: | |
NCBI Full Name: | TIR domain-containing adapter molecule 1 |
NCBI Synonym Full Names: | toll like receptor adaptor molecule 1 |
NCBI Official Symbol: | TICAM1 |
NCBI Official Synonym Symbols: | TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1 |
NCBI Protein Information: | TIR domain-containing adapter molecule 1 |
UniProt Protein Name: | TIR domain-containing adapter molecule 1 |
UniProt Synonym Protein Names: | Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta |
Protein Family: | Trifolitoxin |
UniProt Gene Name: | TICAM1 |
UniProt Entry Name: | TCAM1_HUMAN |