TGS1 Antibody (PACO43840)
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주문- SKU:
- PACO43840
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TGS1 Antibody (PACO43840) |
Antibody SKU: | PACO43840 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Trimethylguanosine synthase protein (714-853AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: TGS1 antibody at 10µg/ml + Mouse skeletal muscle tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 97 kDa Observed band size: 97 kDa | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO43840 at dilution of 1:100 | |
Immunohistochemistry of paraffin-embedded human lung tissue using PACO43840 at dilution of 1:100 |
Background: | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. |
Synonyms: | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N2 methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT), TGS1, HCA137 NCOA6IP PIMT |
UniProt Code: | Q96RS0 |
NCBI GenInfo Identifier: | 317373500 |
NCBI Gene ID: | 96764 |
NCBI Accession: | Q96RS0.3 |
UniProt Related Accession: | Q96RS0 |
Molecular Weight: | 97kDa |
NCBI Full Name: | Trimethylguanosine synthase |
NCBI Synonym Full Names: | trimethylguanosine synthase 1 |
NCBI Official Symbol: | TGS1 |
NCBI Official Synonym Symbols: | PIMT; PIPMT; NCOA6IP |
NCBI Protein Information: | trimethylguanosine synthase |
UniProt Protein Name: | Trimethylguanosine synthase |
UniProt Synonym Protein Names: | CLL-associated antigen KW-2; Cap-specific guanine-N2 methyltransferase; Hepatocellular carcinoma-associated antigen 137; Nuclear receptor coactivator 6-interacting protein; PRIP-interacting protein with methyltransferase motif; PIMT; PIPMT |
Protein Family: | Trimethylguanosine synthase |
UniProt Gene Name: | TGS1 |
UniProt Entry Name: | TGS1_HUMAN |