TDP1 Antibody (PACO43571)
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주문- SKU:
- PACO43571
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TDP1 Antibody (PACO43571) |
Antibody SKU: | PACO43571 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Tyrosyl-DNA phosphodiesterase 1 protein (1-260AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43571 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO43571 at dilution of 1:100. |
Background: | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. |
Synonyms: | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-), TDP1 |
UniProt Protein Function: | TDP1: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. Monomer. Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus. Belongs to the tyrosyl-DNA phosphodiesterase family. |
UniProt Protein Details: | Protein type:Phosphodiesterase; EC 3.1.4.-; DNA repair, damage Chromosomal Location of Human Ortholog: 14q32.11 Cellular Component: cytoplasm; nucleus Molecular Function:tyrosyl-DNA phosphodiesterase activity; protein binding; double-stranded DNA binding; exonuclease activity; single-stranded DNA binding Biological Process: single strand break repair; double-strand break repair; DNA repair Disease: Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy |
NCBI Summary: | The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016] |
UniProt Code: | Q9NUW8 |
NCBI GenInfo Identifier: | 37999797 |
NCBI Gene ID: | 55775 |
NCBI Accession: | Q9NUW8.2 |
UniProt Related Accession: | Q9NUW8 |
Molecular Weight: | Predicted Molecular Mass: 20.4kDaAccurate Molecular Mass: 25kDa |
NCBI Full Name: | Tyrosyl-DNA phosphodiesterase 1 |
NCBI Synonym Full Names: | tyrosyl-DNA phosphodiesterase 1 |
NCBI Official Symbol: | TDP1 |
NCBI Protein Information: | tyrosyl-DNA phosphodiesterase 1 |
UniProt Protein Name: | Tyrosyl-DNA phosphodiesterase 1 |
Protein Family: | Tyrosyl-DNA phosphodiesterase |
UniProt Gene Name: | TDP1 |
UniProt Entry Name: | TYDP1_HUMAN |
Antibodies | ELISA Kits |
Anti-TDP1 Antibody (CAB4849) | Human TDP1 (Tyrosyl-DNA phosphodiesterase 1) ELISA Kit (HUFI06160) |
Anti-TDP1 Antibody (CAB7984) | |
TDP1 Antibody (PACO12687) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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