TCIM Antibody (PACO44232)
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주문- SKU:
- PACO44232
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TCIM Antibody (PACO44232) |
Antibody SKU: | PACO44232 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Transcriptional and immune response regulator protein (1-106AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO44232 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human lung cancer using PACO44232 at dilution of 1:100. |
Background: | Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression. Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling. |
Synonyms: | Transcriptional and immune response regulator (Thyroid cancer protein 1) (TC-1), TCIM, C8orf4 TC1 |
UniProt Protein Function: | C8orf4: May decrease apoptosis. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 8p11.2 Biological Process: apoptosis |
NCBI Summary: | This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011] |
UniProt Code: | Q9NR00 |
NCBI GenInfo Identifier: | 296434443 |
NCBI Gene ID: | 56892 |
NCBI Accession: | Q9NR00.2 |
UniProt Related Accession: | Q9NR00 |
Molecular Weight: | 106 |
NCBI Full Name: | Uncharacterized protein C8orf4 |
NCBI Synonym Full Names: | chromosome 8 open reading frame 4 |
NCBI Official Symbol: | C8orf4 |
NCBI Official Synonym Symbols: | TC1; TC-1 |
NCBI Protein Information: | uncharacterized protein C8orf4; human thyroid cancer 1; thyroid cancer protein 1 |
UniProt Protein Name: | Uncharacterized protein C8orf4 |
UniProt Synonym Protein Names: | Thyroid cancer protein 1; TC-1 |
Protein Family: | Protein |
UniProt Gene Name: | C8orf4 |
UniProt Entry Name: | CH004_HUMAN |
Antibodies |
Anti-C8orf4 Antibody (CAB6241) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |