TBX6 Antibody (PACO49054)
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주문- SKU:
- PACO49054
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TBX6 Antibody (PACO49054) |
Antibody SKU: | PACO49054 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human T-box transcription factor TBX6 protein (295-436AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO49054 at dilution of 1:100. |
Background: | T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). |
Synonyms: | T-box transcription factor TBX6 (T-box protein 6), TBX6 |
UniProt Protein Function: | TBX6: T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 16p11.2 Molecular Function:protein binding Biological Process: anatomical structure morphogenesis; mesoderm development; negative regulation of transcription from RNA polymerase II promoter Disease: Deafness, Autosomal Recessive 67 |
NCBI Summary: | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008] |
UniProt Code: | O95947 |
NCBI GenInfo Identifier: | 115502464 |
NCBI Gene ID: | 6911 |
NCBI Accession: | O95947.2 |
UniProt Secondary Accession: | O95947,Q8TAS4, Q9HA44, |
UniProt Related Accession: | O95947 |
Molecular Weight: | 33,197 Da |
NCBI Full Name: | T-box transcription factor TBX6 |
NCBI Synonym Full Names: | T-box 6 |
NCBI Official Symbol: | TBX6 |
NCBI Official Synonym Symbols: | SCDO5 |
NCBI Protein Information: | T-box transcription factor TBX6 |
UniProt Protein Name: | T-box transcription factor TBX6 |
Protein Family: | T-box transcription factor |
UniProt Gene Name: | TBX6 |
UniProt Entry Name: | TBX6_HUMAN |