TBX3 Antibody (PACO22707)
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주문- SKU:
- PACO22707
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | TBX3 Antibody (PACO22707) |
Antibody SKU: | PACO22707 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human TBX3. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from A549 cells, using TBX3 antibody. |
Background: | Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. |
Synonyms: | T-box protein 3; T-box transcription factor TBX3; |
UniProt Protein Function: | TBX3: Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q24.21 Cellular Component: nucleus Molecular Function:protein binding; sequence-specific DNA binding Biological Process: embryonic forelimb morphogenesis; limbic system development; positive regulation of transcription, DNA-dependent; negative regulation of epithelial cell differentiation; palate development; negative regulation of transcription from RNA polymerase II promoter; female genitalia development; forelimb morphogenesis; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; male genitalia development; heart looping; skeletal development; luteinizing hormone secretion; blood vessel development; specification of organ position; transcription, DNA-dependent; in utero embryonic development; stem cell maintenance; positive regulation of cell cycle; cell aging; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; mesoderm morphogenesis; follicle-stimulating hormone secretion; embryonic digit morphogenesis; negative regulation of myoblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis Disease: Ulnar-mammary Syndrome |
NCBI Summary: | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | O15119 |
NCBI GenInfo Identifier: | 28381401 |
NCBI Gene ID: | 6926 |
NCBI Accession: | O15119.4 |
UniProt Secondary Accession: | O15119,Q8TB20, Q9UKF8, |
UniProt Related Accession: | O15119 |
Molecular Weight: | 743 |
NCBI Full Name: | T-box transcription factor TBX3 |
NCBI Synonym Full Names: | T-box 3 |
NCBI Official Symbol: | TBX3 |
NCBI Official Synonym Symbols: | UMS; XHL; TBX3-ISO |
NCBI Protein Information: | T-box transcription factor TBX3; T-box protein 3; bladder cancer related protein XHL |
UniProt Protein Name: | T-box transcription factor TBX3 |
Protein Family: | T-box transcription factor |
UniProt Gene Name: | TBX3 |
UniProt Entry Name: | TBX3_HUMAN |
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