SYT5 Antibody (PACO15046)
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주문- SKU:
- PACO15046
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SYT5 Antibody (PACO15046) |
Antibody SKU: | PACO15046 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human SYT5 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15046(SYT5 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human thigh malignant fibrous histiocytoma tissue, Primary antibody: PACO15046(SYT5 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 8 hours. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15046(SYT5 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules. May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca2+-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface. |
Synonyms: | Synaptotagmin V |
UniProt Protein Function: | SYT5: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)- dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface. Belongs to the synaptotagmin family. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.42|11p Cellular Component: plasma membrane; synaptic vesicle membrane Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; syntaxin binding Biological Process: calcium ion-dependent exocytosis of neurotransmitter; regulation of calcium ion-dependent exocytosis; synaptic transmission; synaptic vesicle endocytosis; vesicle fusion |
NCBI Summary: | Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011] |
UniProt Code: | O00445 |
NCBI GenInfo Identifier: | 32700066 |
NCBI Gene ID: | 6861 |
NCBI Accession: | O00445.2 |
UniProt Secondary Accession: | O00445,Q86X72, B3KWJ8, B7Z300, |
UniProt Related Accession: | O00445 |
Molecular Weight: | 42,474 Da |
NCBI Full Name: | Synaptotagmin-5 |
NCBI Synonym Full Names: | synaptotagmin 5 |
NCBI Official Symbol: | SYT5 |
NCBI Protein Information: | synaptotagmin-5 |
UniProt Protein Name: | Synaptotagmin-5 |
UniProt Synonym Protein Names: | Synaptotagmin V; SytV |
Protein Family: | Synaptotagmin |
UniProt Gene Name: | SYT5 |
UniProt Entry Name: | SYT5_HUMAN |
Antibodies |
Anti-SYT5 Antibody (CAB15321) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |