SYT4 Antibody (PACO15045)
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주문- SKU:
- PACO15045
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SYT4 Antibody (PACO15045) |
Antibody SKU: | PACO15045 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human SYT4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, Jurkat cells, Primary antibody: PACO15045(SYT4 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15045(SYT4 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus. The proximity of the Synaptotagmin IV gene to markers of several psychiatric disorders suggest an involvement of synaptotagmin IV in human disease. Synaptotagmin V is a dense-core vesicle-specific protein that regulates a specific type of calcium-regulated secretion. Synaptotagmin VI interacts with adaptor protein-2 in a calcium-independent manner. Synaptotagmin VII is widely expressed in non-neuronal tissues. |
Synonyms: | synaptotagmin IV |
UniProt Protein Function: | SYT4: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Belongs to the synaptotagmin family. |
UniProt Protein Details: | Protein type:Calcium-binding; Membrane protein, integral; Vesicle Chromosomal Location of Human Ortholog: 18q12.3 Cellular Component: intracellular membrane-bound organelle; plasma membrane Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; protein binding; syntaxin binding Biological Process: calcium ion-dependent exocytosis of neurotransmitter; regulation of calcium ion-dependent exocytosis; vesicle fusion |
UniProt Code: | Q9H2B2 |
NCBI GenInfo Identifier: | 18202937 |
NCBI Gene ID: | 6860 |
NCBI Accession: | Q9H2B2.1 |
UniProt Secondary Accession: | Q9H2B2,Q9P2K4, B4DEU3, |
UniProt Related Accession: | Q9H2B2 |
Molecular Weight: | 46,064 Da |
NCBI Full Name: | Synaptotagmin-4 |
NCBI Synonym Full Names: | synaptotagmin 4 |
NCBI Official Symbol: | SYT4 |
NCBI Official Synonym Symbols: | HsT1192 |
NCBI Protein Information: | synaptotagmin-4 |
UniProt Protein Name: | Synaptotagmin-4 |
UniProt Synonym Protein Names: | Synaptotagmin IV; SytIV |
Protein Family: | Synaptotagmin |
UniProt Gene Name: | SYT4 |
UniProt Entry Name: | SYT4_HUMAN |