UniProt Protein Function: | SULT1E1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated. Belongs to the sulfotransferase 1 family. |
UniProt Protein Details: | Protein type:EC 2.8.2.4; Transferase; Energy Metabolism - sulfur; Lipid Metabolism - androgen and estrogen Chromosomal Location of Human Ortholog: 4q13.1 Cellular Component: cytosol Molecular Function:steroid sulfotransferase activity; estrone sulfotransferase activity; flavonol 3-sulfotransferase activity; steroid binding Biological Process: steroid metabolic process; estrogen metabolic process; xenobiotic metabolic process; sulfation; female pregnancy; 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
NCBI Summary: | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008] |
UniProt Code: | P49888 |
NCBI GenInfo Identifier: | 1711604 |
NCBI Gene ID: | 6783 |
NCBI Accession: | P49888.1 |
UniProt Related Accession: | P49888 |
Molecular Weight: | 35kDa |
NCBI Full Name: | Estrogen sulfotransferase |
NCBI Synonym Full Names: | sulfotransferase family 1E member 1 |
NCBI Official Symbol: | SULT1E1 |
NCBI Official Synonym Symbols: | EST; STE; EST-1; ST1E1 |
NCBI Protein Information: | estrogen sulfotransferase |
UniProt Protein Name: | Estrogen sulfotransferase |
UniProt Synonym Protein Names: | EST-1; Sulfotransferase 1E1; ST1E1; Sulfotransferase, estrogen-preferring |
Protein Family: | Estrogen sulfotransferase |
UniProt Gene Name: | SULT1E1 |
UniProt Entry Name: | ST1E1_HUMAN |