STT3B Antibody (PACO12552)
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주문- SKU:
- PACO12552
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | STT3B Antibody (PACO12552) |
Antibody SKU: | PACO12552 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human STT3B |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae);STT3B;FLJ90106;SIMP;STT3-B ; |
UniProt Protein Function: | Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation. |
NCBI Summary: | The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014] |
UniProt Code: | Q8TCJ2 |
NCBI GenInfo Identifier: | 30578410 |
NCBI Gene ID: | 201595 |
NCBI Accession: | NP_849193.1 |
UniProt Secondary Accession: | Q8TCJ2,Q96JZ4, Q96KY7, |
UniProt Related Accession: | Q8TCJ2 |
Molecular Weight: | Calculated MW: 93kDaObserved MW: Refer to figures |
NCBI Full Name: | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B |
NCBI Synonym Full Names: | STT3B, catalytic subunit of the oligosaccharyltransferase complex |
NCBI Official Symbol: | STT3B |
NCBI Official Synonym Symbols: | SIMP; CDG1X; STT3-B |
NCBI Protein Information: | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B |
UniProt Protein Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B |
UniProt Synonym Protein Names: | Source of immunodominant MHC-associated peptides homolog |
Protein Family: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase |
UniProt Gene Name: | STT3B |