STRAP Antibody (PACO12547)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO12547
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | STRAP Antibody (PACO12547) |
Antibody SKU: | PACO12547 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human STRAP |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | serine/threonine kinase receptor associated protein;STRAP;MAWD;PT-WD;UNRIP ; |
UniProt Protein Function: | STRAP: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Belongs to the WD repeat STRAP family. |
UniProt Protein Details: | Protein type:RNA splicing; Adaptor/scaffold Chromosomal Location of Human Ortholog: 12p12.3 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; SMN complex; nucleus; cytosol Molecular Function:protein binding; receptor binding Biological Process: spliceosomal snRNP biogenesis; transforming growth factor beta receptor signaling pathway; maintenance of gastrointestinal epithelium; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of epithelial cell proliferation |
UniProt Code: | Q9Y3F4 |
NCBI GenInfo Identifier: | 12643951 |
NCBI Gene ID: | 11171 |
NCBI Accession: | Q9Y3F4.1 |
UniProt Secondary Accession: | Q9Y3F4,Q5TZT4, Q9NTK0, Q9UQC8, B2R5S5, B4DNJ6, |
UniProt Related Accession: | Q9Y3F4 |
Molecular Weight: | 350 |
NCBI Full Name: | Serine-threonine kinase receptor-associated protein |
NCBI Synonym Full Names: | serine/threonine kinase receptor associated protein |
NCBI Official Symbol: | STRAP |
NCBI Official Synonym Symbols: | MAWD; PT-WD; UNRIP |
NCBI Protein Information: | serine-threonine kinase receptor-associated protein; unr-interacting protein; WD-40 repeat protein PT-WD; MAP activator with WD repeats |
UniProt Protein Name: | Serine-threonine kinase receptor-associated protein |
UniProt Synonym Protein Names: | MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD |
Protein Family: | Serine-threonine kinase receptor-associated protein |
UniProt Gene Name: | STRAP |
UniProt Entry Name: | STRAP_HUMAN |