STRADB Antibody (PACO15412)
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주문- SKU:
- PACO15412
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | STRADB Antibody (PACO15412) |
Antibody SKU: | PACO15412 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human STRADB |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15412(STRADB Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Mouse pancreas tissue, Mouse spleen tissue, mouse heart tissue, 293T cells, Primary antibody: PACO15412(STRADB Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human lymphoma tissue using PACO15412(STRADB Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | STE20-related kinase adaptor beta |
UniProt Protein Function: | STLK6: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Motility/polarity/chemotaxis; STE group; STE20 family; STLK subfamily Chromosomal Location of Human Ortholog: 2q33.1 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:protein binding; protein kinase activity Biological Process: activation of protein kinase activity; cell cycle arrest; protein amino acid phosphorylation; protein export from nucleus |
NCBI Summary: | This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] |
UniProt Code: | Q9C0K7 |
NCBI GenInfo Identifier: | 74762722 |
NCBI Gene ID: | 55437 |
NCBI Accession: | Q9C0K7.1 |
UniProt Secondary Accession: | Q9C0K7,Q5BKY7, Q9P1L0, |
UniProt Related Accession: | Q9C0K7 |
Molecular Weight: | 31,219 Da |
NCBI Full Name: | STE20-related kinase adapter protein beta |
NCBI Synonym Full Names: | STE20-related kinase adaptor beta |
NCBI Official Symbol: | STRADB |
NCBI Official Synonym Symbols: | PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038 |
NCBI Protein Information: | STE20-related kinase adapter protein beta |
UniProt Protein Name: | STE20-related kinase adapter protein beta |
UniProt Synonym Protein Names: | Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; Pseudokinase ALS2CR2 |
Protein Family: | STE20-related kinase adapter protein |
UniProt Gene Name: | STRADB |
UniProt Entry Name: | STRAB_HUMAN |