UniProt Protein Function: | ST8SIA2: May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression. Belongs to the glycosyltransferase 29 family. |
UniProt Protein Details: | Protein type:EC 2.4.99.-; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, integral; Transferase Chromosomal Location of Human Ortholog: 15q26 Cellular Component: Golgi membrane; recycling endosome; early endosome; integral to Golgi membrane Molecular Function:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity; sialic acid binding Biological Process: axon guidance; nervous system development; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; carbohydrate metabolic process; protein modification process; protein amino acid glycosylation; protein amino acid N-linked glycosylation via asparagine; N-glycan processing; post-translational protein modification; oligosaccharide metabolic process; ganglioside biosynthetic process |
NCBI Summary: | The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q92186 |
NCBI GenInfo Identifier: | 2494831 |
NCBI Gene ID: | 8128 |
NCBI Accession: | Q92186.1 |
UniProt Secondary Accession: | Q92186,Q4VAZ0, Q92470, Q92746, |
UniProt Related Accession: | Q92186 |
Molecular Weight: | 42,430 Da |
NCBI Full Name: | Alpha-2,8-sialyltransferase 8B |
NCBI Synonym Full Names: | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 |
NCBI Official Symbol: | ST8SIA2 |
NCBI Official Synonym Symbols: | STX; SIAT8B; HsT19690; ST8SIA-II |
NCBI Protein Information: | alpha-2,8-sialyltransferase 8B; SIAT8-B; ST8SiaII; sialyltransferase X; sialytransferase St8Sia II; sialyltransferase St8Sia II; alpha-2,8-sialyltransferase 8B 1; sialyltransferase 8 (alpha-2, 8-sialytransferase) B |
UniProt Protein Name: | Alpha-2,8-sialyltransferase 8B |
UniProt Synonym Protein Names: | Sialyltransferase 8B; SIAT8-B; Sialyltransferase St8Sia II; ST8SiaII; Sialyltransferase X; STX |
Protein Family: | Alpha-2,8-sialyltransferase |
UniProt Gene Name: | ST8SIA2 |
UniProt Entry Name: | SIA8B_HUMAN |