ST14 Antibody (PACO43032)
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주문- SKU:
- PACO43032
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ST14 Antibody (PACO43032) |
Antibody SKU: | PACO43032 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Suppressor of tumorigenicity 14 protein (566-855AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO43032 at dilution of 1:100. |
Background: | Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. |
Synonyms: | Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein), ST14, PRSS14 SNC19 TADG15 |
UniProt Protein Function: | ST14: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH). ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair. Belongs to the peptidase S1 family. |
UniProt Protein Details: | Protein type:EC 3.4.21.109; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 11q24-q25 Cellular Component: extrinsic to plasma membrane; extracellular space; integral to plasma membrane; basolateral plasma membrane; plasma membrane Molecular Function:serine-type peptidase activity; serine-type endopeptidase activity Biological Process: keratinocyte differentiation; proteolysis Disease: Ichthyosis, Congenital, Autosomal Recessive 11 |
UniProt Code: | Q9Y5Y6 |
NCBI GenInfo Identifier: | 11415040 |
NCBI Gene ID: | 6768 |
NCBI Accession: | NP_068813 |
UniProt Secondary Accession: | Q9Y5Y6,Q9BS01, Q9H3S0, Q9HB36, Q9HCA3, |
UniProt Related Accession: | Q9Y5Y6 |
Molecular Weight: | 94,770 Da |
NCBI Full Name: | suppressor of tumorigenicity 14 protein |
NCBI Synonym Full Names: | suppression of tumorigenicity 14 (colon carcinoma) |
NCBI Official Symbol: | ST14 |
NCBI Official Synonym Symbols: | HAI; MTSP1; SNC19; ARCI11; MT-SP1; PRSS14; TADG15; TMPRSS14 |
NCBI Protein Information: | suppressor of tumorigenicity 14 protein; membrane-type serine protease 1; prostamin; serine protease 14; serine protease TADG-15; suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin); tumor associated differentially expressed gene 15 pr |
UniProt Protein Name: | Suppressor of tumorigenicity 14 protein |
UniProt Synonym Protein Names: | Matriptase; Membrane-type serine protease 1; MT-SP1; Prostamin; Serine protease 14; Serine protease TADG-15; Tumor-associated differentially-expressed gene 15 protein |
Protein Family: | Suppressor of tumorigenicity 14 protein |
UniProt Gene Name: | ST14 |
UniProt Entry Name: | ST14_HUMAN |