ST14 Antibody (PACO14686)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO14686
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ST14 Antibody (PACO14686) |
Antibody SKU: | PACO14686 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human ST14 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14686(ST14 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO14686(ST14 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. |
Synonyms: | suppression of tumorigenicity 14 (colon carcinoma) |
UniProt Protein Function: | ST14: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH). ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair. Belongs to the peptidase S1 family. |
UniProt Protein Details: | Protein type:EC 3.4.21.109; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 11q24-q25 Cellular Component: extrinsic to plasma membrane; extracellular space; integral to plasma membrane; basolateral plasma membrane; plasma membrane Molecular Function:serine-type peptidase activity; serine-type endopeptidase activity Biological Process: keratinocyte differentiation; proteolysis Disease: Ichthyosis, Congenital, Autosomal Recessive 11 |
UniProt Code: | Q9Y5Y6 |
NCBI GenInfo Identifier: | 11415040 |
NCBI Gene ID: | 6768 |
NCBI Accession: | NP_068813 |
UniProt Secondary Accession: | Q9Y5Y6,Q9BS01, Q9H3S0, Q9HB36, Q9HCA3, |
UniProt Related Accession: | Q9Y5Y6 |
Molecular Weight: | 94,770 Da |
NCBI Full Name: | suppressor of tumorigenicity 14 protein |
NCBI Synonym Full Names: | suppression of tumorigenicity 14 (colon carcinoma) |
NCBI Official Symbol: | ST14 |
NCBI Official Synonym Symbols: | HAI; MTSP1; SNC19; ARCI11; MT-SP1; PRSS14; TADG15; TMPRSS14 |
NCBI Protein Information: | suppressor of tumorigenicity 14 protein; membrane-type serine protease 1; prostamin; serine protease 14; serine protease TADG-15; suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin); tumor associated differentially expressed gene 15 pr |
UniProt Protein Name: | Suppressor of tumorigenicity 14 protein |
UniProt Synonym Protein Names: | Matriptase; Membrane-type serine protease 1; MT-SP1; Prostamin; Serine protease 14; Serine protease TADG-15; Tumor-associated differentially-expressed gene 15 protein |
Protein Family: | Suppressor of tumorigenicity 14 protein |
UniProt Gene Name: | ST14 |
UniProt Entry Name: | ST14_HUMAN |