SPIN1 Antibody (PACO44224)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO44224
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SPIN1 Antibody (PACO44224) |
Antibody SKU: | PACO44224 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Spindlin-1 protein (1-262AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: SPIN1 antibody at 1.45µg/ml. Lane 1: Hela whole cell lysate. Lane 2: 293T whole cell lysate. Lane 3: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 30 kDa. Observed band size: 30 kDa.. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44224 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO44224 at dilution of 1:100. |
Background: | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. |
Synonyms: | Spindlin-1 (Ovarian cancer-related protein) (Spindlin1), SPIN1, OCR SPIN |
UniProt Protein Function: | SPIN1: May play a role in cell-cycle regulation during the transition from gamete to embryo. Belongs to the SPIN/STSY family. |
UniProt Protein Details: | Protein type:Nucleolus; DNA-binding Chromosomal Location of Human Ortholog: 9q22.1 Cellular Component: nucleolus; spindle; nucleus Molecular Function:protein binding; methylated histone residue binding Biological Process: Wnt receptor signaling pathway; meiotic cell cycle; multicellular organismal development; gamete generation; chromatin modification; positive regulation of Wnt receptor signaling pathway; rRNA transcription |
UniProt Code: | Q9Y657 |
NCBI GenInfo Identifier: | 93141317 |
NCBI Gene ID: | 10927 |
NCBI Accession: | Q9Y657.3 |
UniProt Secondary Accession: | Q9Y657,Q7KZJ8, Q9GZT2, Q9H0N7, A8K0X6, B3KRQ4, |
UniProt Related Accession: | Q9Y657 |
Molecular Weight: | Calculated MW: 29kDaObserved MW: 32kDa |
NCBI Full Name: | Spindlin-1 |
NCBI Synonym Full Names: | spindlin 1 |
NCBI Official Symbol: | SPIN1 |
NCBI Official Synonym Symbols: | SPIN |
NCBI Protein Information: | spindlin-1; ovarian cancer-related protein; spindlin1 |
UniProt Protein Name: | Spindlin-1 |
UniProt Synonym Protein Names: | Ovarian cancer-related protein; Spindlin1 |
Protein Family: | Spindlin |
UniProt Gene Name: | SPIN1 |
UniProt Entry Name: | SPIN1_HUMAN |