SPAG8 Antibody (PACO12416)
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주문- SKU:
- PACO12416
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SPAG8 Antibody (PACO12416) |
Antibody SKU: | PACO12416 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse |
Immunogen: | Human SPAG8 |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | sperm associated antigen 8;SPAG8;BS-84;HSD-1;MGC26201;SMP1;SPAG3;hSMP-1 ; |
UniProt Protein Function: | SPAG8: May play a role in fertility and microtubule formation through interaction with RANBP9. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: 9p13.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding Biological Process: positive regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q99932 |
NCBI GenInfo Identifier: | 62511128 |
NCBI Gene ID: | 26206 |
NCBI Accession: | Q99932.2 |
UniProt Secondary Accession: | Q99932,Q12937, Q5TCV8, Q8WWB4, B4DY89, E9PDV6, |
UniProt Related Accession: | Q99932 |
Molecular Weight: | 51,139 Da |
NCBI Full Name: | Sperm-associated antigen 8 |
NCBI Synonym Full Names: | sperm associated antigen 8 |
NCBI Official Symbol: | SPAG8 |
NCBI Official Synonym Symbols: | SMP1; BS-84; CT142; HSD-1; SPAG3; CILD28; hSMP-1 |
NCBI Protein Information: | sperm-associated antigen 8 |
UniProt Protein Name: | Sperm-associated antigen 8 |
UniProt Synonym Protein Names: | HSD-1; Sperm membrane protein 1; SMP-1; Sperm membrane protein BS-84 |
Protein Family: | Sperm-associated antigen |
UniProt Gene Name: | SPAG8 |
UniProt Entry Name: | SPAG8_HUMAN |