SOCS6 Antibody (PACO15017)
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주문- SKU:
- PACO15017
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SOCS6 Antibody (PACO15017) |
Antibody SKU: | PACO15017 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human SOCS6 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO15017(SOCS6 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15017(SOCS6 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. |
Synonyms: | suppressor of cytokine signaling 6 |
UniProt Protein Function: | SOCS6: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 18q22.2 Cellular Component: cytoplasm; immunological synapse Molecular Function:protein binding; protein kinase inhibitor activity Biological Process: cytokine and chemokine mediated signaling pathway; defense response; JAK-STAT cascade; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; proteasomal protein catabolic process |
NCBI Summary: | The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008] |
UniProt Code: | O14544 |
NCBI GenInfo Identifier: | 206729895 |
NCBI Gene ID: | 9306 |
NCBI Accession: | O14544.2 |
UniProt Secondary Accession: | O14544,Q8WUM3, |
UniProt Related Accession: | O14544 |
Molecular Weight: | 59,528 Da |
NCBI Full Name: | Suppressor of cytokine signaling 6 |
NCBI Synonym Full Names: | suppressor of cytokine signaling 6 |
NCBI Official Symbol: | SOCS6 |
NCBI Official Synonym Symbols: | CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060 |
NCBI Protein Information: | suppressor of cytokine signaling 6 |
UniProt Protein Name: | Suppressor of cytokine signaling 6 |
UniProt Synonym Protein Names: | Cytokine-inducible SH2 protein 4; CIS-4; Suppressor of cytokine signaling 4; SOCS-4 |
Protein Family: | Suppressor of cytokine signaling |
UniProt Gene Name: | SOCS6 |
UniProt Entry Name: | SOCS6_HUMAN |