SOCS5 Antibody (PACO45516)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO45516
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | SOCS5 Antibody (PACO45516) |
Antibody SKU: | PACO45516 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Suppressor of cytokine signaling 5 protein (1-270AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO45516 at dilution of 1:100. |
Background: | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. |
Synonyms: | Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5), SOCS5, CIS6 CISH5 CISH6 KIAA0671 |
UniProt Protein Function: | SOCS5: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 2p21 Cellular Component: cytoplasm Molecular Function:protein binding; protein kinase inhibitor activity; receptor tyrosine kinase binding; epidermal growth factor receptor binding Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor activity; negative regulation of T-helper 2 cell differentiation; regulation of growth; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; cytokine and chemokine mediated signaling pathway; protein ubiquitination; cell growth; positive regulation of T-helper 1 cell differentiation; JAK-STAT cascade; negative regulation of JAK-STAT cascade; negative regulation of signal transduction |
NCBI Summary: | The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | O75159 |
NCBI GenInfo Identifier: | 7662240 |
NCBI Gene ID: | 9655 |
NCBI Accession: | NP_054730 |
UniProt Secondary Accession: | O75159,Q53SD4, Q8IYZ4, |
UniProt Related Accession: | O75159 |
Molecular Weight: | 61,246 Da |
NCBI Full Name: | suppressor of cytokine signaling 5 |
NCBI Synonym Full Names: | suppressor of cytokine signaling 5 |
NCBI Official Symbol: | SOCS5 |
NCBI Official Synonym Symbols: | CIS6; CISH6; Cish5; SOCS-5 |
NCBI Protein Information: | suppressor of cytokine signaling 5 |
UniProt Protein Name: | Suppressor of cytokine signaling 5 |
UniProt Synonym Protein Names: | Cytokine-inducible SH2 protein 6; CIS-6; Cytokine-inducible SH2-containing protein 5 |
Protein Family: | Suppressor of cytokine signaling |
UniProt Gene Name: | SOCS5 |
UniProt Entry Name: | SOCS5_HUMAN |