SOCS4 Antibody (PACO45035)
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주문- SKU:
- PACO45035
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SOCS4 Antibody (PACO45035) |
Antibody SKU: | PACO45035 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Suppressor of cytokine signaling 4 protein (1-270AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: SOCS4 antibody at 4.39 µg/ml. Lane 1: Mouse kidney tissue. Lane 2: Jurkat whole cell lysate. Lane 3: A549 whole cell lysate. Lane 4: 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 60 kDa. Observed band size: 60 kDa.. | |
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO45035 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO45035 at dilution of 1:100. |
Background: | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. |
Synonyms: | Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7), SOCS4, SOCS7 |
UniProt Protein Function: | SOCS4: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 14q22.1 Cellular Component: cytoplasm Molecular Function:protein binding; protein kinase inhibitor activity Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of epidermal growth factor receptor activity; negative regulation of JAK-STAT cascade |
NCBI Summary: | The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8WXH5 |
NCBI GenInfo Identifier: | 20178106 |
NCBI Gene ID: | 122809 |
NCBI Accession: | Q8WXH5.1 |
UniProt Related Accession: | Q8WXH5 |
Molecular Weight: | 50,623 Da |
NCBI Full Name: | Suppressor of cytokine signaling 4 |
NCBI Synonym Full Names: | suppressor of cytokine signaling 4 |
NCBI Official Symbol: | SOCS4 |
NCBI Official Synonym Symbols: | SOCS7 |
NCBI Protein Information: | suppressor of cytokine signaling 4 |
UniProt Protein Name: | Suppressor of cytokine signaling 4 |
UniProt Synonym Protein Names: | Suppressor of cytokine signaling 7; SOCS-7 |
Protein Family: | Suppressor of cytokine signaling |
UniProt Gene Name: | SOCS4 |
UniProt Entry Name: | SOCS4_HUMAN |
Antibodies | ELISA Kits |
Anti-SOCS4 Antibody (CAB8003) | Human SOCS4 (Suppressor Of Cytokine Signaling 4) ELISA Kit (HUFI08042) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |