UniProt Protein Function: | SOAT1: Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. |
UniProt Protein Details: | Protein type:Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; EC 2.3.1.26; Transferase; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1q25 Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane Molecular Function:protein binding; acyl-CoA binding; sterol O-acyltransferase activity; cholesterol binding Biological Process: cholesterol metabolic process; cholesterol homeostasis; cholesterol efflux; positive regulation of amyloid precursor protein biosynthetic process |
NCBI Summary: | The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011] |
UniProt Code: | P35610 |
NCBI GenInfo Identifier: | 33302623 |
NCBI Gene ID: | 6646 |
NCBI Accession: | P35610.3 |
UniProt Secondary Accession: | P35610,Q5T0X4, Q8N1E4, A6NC40, A8K3P4, A9Z1V7, B4DU95 |
UniProt Related Accession: | P35610 |
Molecular Weight: | 550 |
NCBI Full Name: | Sterol O-acyltransferase 1 |
NCBI Synonym Full Names: | sterol O-acyltransferase 1 |
NCBI Official Symbol: | SOAT1 |
NCBI Official Synonym Symbols: | ACAT; SOAT; STAT; ACACT; ACAT1; ACAT-1 |
NCBI Protein Information: | sterol O-acyltransferase 1; acyl-coenzyme A:cholesterol acyltransferase 1; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 |
UniProt Protein Name: | Sterol O-acyltransferase 1 |
UniProt Synonym Protein Names: | Acyl-coenzyme A:cholesterol acyltransferase 1; ACAT-1; Cholesterol acyltransferase 1 |
Protein Family: | Sterol O-acyltransferase |
UniProt Gene Name: | SOAT1 |
UniProt Entry Name: | SOAT1_HUMAN |