SNX15 Antibody (PACO17129)
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주문- SKU:
- PACO17129
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SNX15 Antibody (PACO17129) |
Antibody SKU: | PACO17129 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:20-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human SNX15 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17129(SNX15 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17129(SNX15 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. |
Synonyms: | sorting nexin 15 |
UniProt Protein Function: | SNX15: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q12 Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleolus Molecular Function:protein binding; protein serine/threonine kinase activity Biological Process: signal transduction |
NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q9NRS6 |
NCBI GenInfo Identifier: | 13124562 |
NCBI Gene ID: | 29907 |
NCBI Accession: | Q9NRS6.1 |
UniProt Secondary Accession: | Q9NRS6,Q9NRS5, E5KQS6, |
UniProt Related Accession: | Q9NRS6 |
Molecular Weight: | 29,220 Da |
NCBI Full Name: | Sorting nexin-15 |
NCBI Synonym Full Names: | sorting nexin 15 |
NCBI Official Symbol: | SNX15 |
NCBI Official Synonym Symbols: | HSAF001435 |
NCBI Protein Information: | sorting nexin-15 |
UniProt Protein Name: | Sorting nexin-15 |
Protein Family: | Sorting nexin |
UniProt Gene Name: | SNX15 |
UniProt Entry Name: | SNX15_HUMAN |