SNX1 Antibody (PACO01522)
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주문- SKU:
- PACO01522
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SNX1 Antibody |
Antibody SKU: | PACO01522 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human SNX1. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | SNX1; Sorting nexin-1 |
UniProt Protein Function: | SNX1: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 15q22.31 Cellular Component: cytoplasm; early endosome membrane; endosome membrane; extrinsic to membrane; intracellular membrane-bound organelle; membrane; protein complex; retromer complex Molecular Function:epidermal growth factor receptor binding; identical protein binding; insulin receptor binding; phosphoinositide binding; protein binding; protein heterodimerization activity; protein homodimerization activity Biological Process: intracellular protein transport; receptor internalization; retrograde transport, endosome to Golgi; vesicle organization and biogenesis |
NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13596 |
NCBI GenInfo Identifier: | 17380569 |
NCBI Gene ID: | 6642 |
NCBI Accession: | Q13596.3 |
UniProt Secondary Accession: | Q13596,O60750, O60751, Q6ZRJ8, A6NM19, A8K6T7, H0Y2M5 |
UniProt Related Accession: | Q13596 |
Molecular Weight: | 63,082 Da |
NCBI Full Name: | Sorting nexin-1 |
NCBI Synonym Full Names: | sorting nexin 1 |
NCBI Official Symbol: | SNX1 |
NCBI Official Synonym Symbols: | VPS5; HsT17379 |
NCBI Protein Information: | sorting nexin-1 |
UniProt Protein Name: | Sorting nexin-1 |
Protein Family: | Sorting nexin |
UniProt Gene Name: | SNX1 |
UniProt Entry Name: | SNX1_HUMAN |