SNAI1 (Ab-246) Antibody (PACO21587)
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주문- SKU:
- PACO21587
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SNAI1 (Ab-246) Antibody (PACO21587) |
Antibody SKU: | PACO21587 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized non-phosphopeptide derived from human SNAI1 around the phosphorylation site of serine 246 (T-F-S(p)-R-M). |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from HT29 cells, using SNAI1 (Ab-246) antibody. |
Background: | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. Twigg S.R., Hum. Genet. 105:320-326(1999). |
Synonyms: | SNAH; SNAI; Sna; Snail; zinc finger protein SNAI1 |
UniProt Protein Function: | Snail1: a protein of the C2H2-type zinc-finger family that regulates transcription. Involved in embryonic mesoderm formation. Plays a role in the epithelial to mesenchymal transition (EMT). EMT is characterized by decreased levels of the epithelial markers E-cadherin and alpha- and beta-catenin, and increased cellular migration and expression of the mesenchymal markers fibronectin, vimentin, N-cadherin and smooth muscle alpha-actin.E Snail binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription. NF-kappaB binds and regulates the snail promoter and is critical for EMT, and inhibition of NF-kappaB activity lowered snail levels and morphologically reversed the EMT. |
UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; Transcription factor Chromosomal Location of Human Ortholog: 20q13.2 Cellular Component: cytoplasm; nucleus Molecular Function:kinase binding; protein binding Biological Process: epithelial to mesenchymal transition; mesoderm formation; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; positive regulation of cell migration; positive regulation of transcription, DNA-dependent |
NCBI Summary: | The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95863 |
NCBI GenInfo Identifier: | 12644089 |
NCBI Gene ID: | 6615 |
NCBI Accession: | O95863.2 |
UniProt Secondary Accession: | O95863,Q9P113, Q9UBP7, Q9UHH7, B2R842, |
UniProt Related Accession: | O95863 |
Molecular Weight: | 29,083 Da |
NCBI Full Name: | Zinc finger protein SNAI1 |
NCBI Synonym Full Names: | snail family transcriptional repressor 1 |
NCBI Official Symbol: | SNAI1 |
NCBI Official Synonym Symbols: | SNA; SNAH; SNAIL; SLUGH2; SNAIL1; dJ710H13.1 |
NCBI Protein Information: | zinc finger protein SNAI1 |
UniProt Protein Name: | Zinc finger protein SNAI1 |
UniProt Synonym Protein Names: | Protein snail homolog 1; Protein sna |
Protein Family: | Protein snail |
UniProt Gene Name: | SNAI1 |
UniProt Entry Name: | SNAI1_HUMAN |
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