SMC2 Antibody (PACO20552)
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주문- SKU:
- PACO20552
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SMC2 Antibody (PACO20552) |
Antibody SKU: | PACO20552 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human SMC2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane 1-3: Jurkat cells, A172 cells, A549 cells, Primary antibody: PACO20552(SMC2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
Background: | Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals. |
Synonyms: | structural maintenance of chromosomes 2 |
UniProt Protein Function: | SMC2L1: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Belongs to the SMC family. SMC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 9q31.1 Cellular Component: condensed chromosome; condensin complex; cytoplasm; cytosol; nuclear chromosome; nucleolus; nucleoplasm; nucleus Molecular Function:protein binding; protein heterodimerization activity Biological Process: mitotic chromosome condensation |
UniProt Code: | O95347 |
NCBI GenInfo Identifier: | 215273886 |
NCBI Gene ID: | 10592 |
NCBI Accession: | O95347.2 |
UniProt Secondary Accession: | O95347,Q6IEE0, Q9P1P2, |
UniProt Related Accession: | O95347 |
Molecular Weight: | 124,926 Da |
NCBI Full Name: | Structural maintenance of chromosomes protein 2 |
NCBI Synonym Full Names: | structural maintenance of chromosomes 2 |
NCBI Official Symbol: | SMC2 |
NCBI Official Synonym Symbols: | CAPE; CAP-E; SMC-2; SMC2L1 |
NCBI Protein Information: | structural maintenance of chromosomes protein 2 |
UniProt Protein Name: | Structural maintenance of chromosomes protein 2 |
UniProt Synonym Protein Names: | Chromosome-associated protein E; hCAP-E; XCAP-E homolog |
UniProt Gene Name: | SMC2 |
UniProt Entry Name: | SMC2_HUMAN |
Antibodies |
Anti-SMC2 Antibody (CAB17867) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |