SLC7A11 Antibody (PACO20931)
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주문- SKU:
- PACO20931
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SLC7A11 Antibody (PACO20931) |
Antibody SKU: | PACO20931 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:20-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human SLC7A11 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20931(SLC7A11 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-2: K562 and hepg2 cell, Primary antibody: PACO20931(SLC7A11 Antibody) at dilution 1/300 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20931(SLC7A11 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid, transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. |
Synonyms: | solute carrier family 7 (anionic amino acid, transporter light chain, xc- system), member 11 |
UniProt Protein Function: | Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. |
NCBI Summary: | This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011] |
UniProt Code: | Q9UPY5 |
NCBI GenInfo Identifier: | 7657683 |
NCBI Gene ID: | 23657 |
NCBI Accession: | NP_055146.1 |
UniProt Secondary Accession: | Q9UPY5,A8K2U4, |
UniProt Related Accession: | Q9UPY5 |
Molecular Weight: | Observed: 40 kDa-45 kDaPredicted: 56 kDa |
NCBI Full Name: | cystine/glutamate transporter |
NCBI Synonym Full Names: | solute carrier family 7 member 11 |
NCBI Official Symbol: | SLC7A11 |
NCBI Official Synonym Symbols: | xCT; CCBR1 |
NCBI Protein Information: | cystine/glutamate transporter |
UniProt Protein Name: | Cystine/glutamate transporter |
UniProt Synonym Protein Names: | Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT |
Protein Family: | Protein XAP5 CIRCADIAN TIMEKEEPER |
UniProt Gene Name: | SLC7A11 |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |