SLC2A4 Antibody (PACO29944)
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주문- SKU:
- PACO29944
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | SLC2A4 Antibody (PACO29944) |
Antibody SKU: | PACO29944 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Solute carrier family 2, facilitated glucose transporter member 4 protein (223-287AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: SLC2A4 antibody at 2µg/ml Lane 1: Mouse heart tissue Lane 2: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 55, 44 kDa Observed band size: 55 kDa . | |
Immunofluorescent analysis of Hela cells using PACO29944 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry analysis of human skeletal muscle tissue using PACO29944 at dilution of 1:100. |
Background: | Insulin-regulated facilitative glucose transporter. |
Synonyms: | Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4), SLC2A4, GLUT4 |
UniProt Protein Function: | GLUT4: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Its surface expression is regulated by insulin. Has two internalization sequences, a dileucine repeat present in the C-terminus and a FxxY motif in the amino-terminal end. Associates with an intracellular tubulo-vesicular compartment under low plasma conditions. The binding of insulin to the insulin receptor (a typosine kinase) leads to the rapid translocation of GLUT4 to the cell surface, increasing cellular glucose transport activity. Its translocation to the plasma membrane is also stimulated by exercise, but independent from insulin signaling. This insulin-independent pathway may be regulated by AMPK. |
UniProt Protein Details: | Protein type:Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13 Cellular Component: multivesicular body; trans-Golgi network transport vesicle; membrane; clathrin-coated vesicle; integral to plasma membrane; perinuclear region of cytoplasm; T-tubule; plasma membrane; endomembrane system; coated pit; vesicle membrane; cytosol; lipid raft; external side of plasma membrane Molecular Function:D-glucose transmembrane transporter activity; protein binding; glucose transmembrane transporter activity Biological Process: amylopectin biosynthetic process; response to ethanol; cellular response to insulin stimulus; glucose import; hexose transport; carbohydrate metabolic process; brown fat cell differentiation; pathogenesis; glucose transport; glucose homeostasis; transmembrane transport Disease: Diabetes Mellitus, Noninsulin-dependent |
NCBI Summary: | This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008] |
UniProt Code: | P14672 |
NCBI GenInfo Identifier: | 121761 |
NCBI Gene ID: | 6517 |
NCBI Accession: | P14672.1 |
UniProt Secondary Accession: | P14672,Q05BQ3, Q14CX2, |
UniProt Related Accession: | P14672 |
Molecular Weight: | 509 |
NCBI Full Name: | Solute carrier family 2, facilitated glucose transporter member 4 |
NCBI Synonym Full Names: | solute carrier family 2 (facilitated glucose transporter), member 4 |
NCBI Official Symbol: | SLC2A4 |
NCBI Official Synonym Symbols: | GLUT4 |
NCBI Protein Information: | solute carrier family 2, facilitated glucose transporter member 4; GLUT-4; insulin-responsive glucose transporter type 4; glucose transporter type 4, insulin-responsive |
UniProt Protein Name: | Solute carrier family 2, facilitated glucose transporter member 4 |
UniProt Synonym Protein Names: | Glucose transporter type 4, insulin-responsive; GLUT-4 |
UniProt Gene Name: | SLC2A4 |
UniProt Entry Name: | GTR4_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |