SLC29A1 Antibody (PACO48074)
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주문- SKU:
- PACO48074
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SLC29A1 Antibody (PACO48074) |
Antibody SKU: | PACO48074 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Equilibrative nucleoside transporter 1 protein (228-291AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Mouse skeletal muscle tissue. All lanes: KIR2DL3 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 51, 59 kDa. Observed band size: 38 kDa.. | |
Immunofluorescent analysis of U251 cells using PACO48074 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO48074 at dilution of 1:100. |
Background: | Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). |
Synonyms: | Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1), SLC29A1, ENT1 |
UniProt Protein Function: | SLC29A1: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. |
UniProt Protein Details: | Protein type:Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: apical plasma membrane; basolateral plasma membrane; membrane; plasma membrane Molecular Function:nucleoside transmembrane transporter activity Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleoside transport |
NCBI Summary: | This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99808 |
NCBI GenInfo Identifier: | 9296956 |
NCBI Gene ID: | 2030 |
NCBI Accession: | Q99808.3 |
UniProt Secondary Accession: | Q99808,Q5T9W9, Q9UJY2, B3KQV7, B3KQY5, |
UniProt Related Accession: | Q99808 |
Molecular Weight: | 58,963 Da |
NCBI Full Name: | Equilibrative nucleoside transporter 1 |
NCBI Synonym Full Names: | solute carrier family 29 member 1 (Augustine blood group) |
NCBI Official Symbol: | SLC29A1 |
NCBI Official Synonym Symbols: | ENT1 |
NCBI Protein Information: | equilibrative nucleoside transporter 1 |
UniProt Protein Name: | Equilibrative nucleoside transporter 1 |
UniProt Synonym Protein Names: | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1 |
Protein Family: | Equilibrative nucleoside transporter |
UniProt Gene Name: | SLC29A1 |
UniProt Entry Name: | S29A1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |