SLC27A2 Antibody (PACO12276)
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주문- SKU:
- PACO12276
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | SLC27A2 Antibody (PACO12276) |
Antibody SKU: | PACO12276 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human SLC27A2 |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | solute carrier family 27 (fatty acid, transporter), member 2;SLC27A2;ACSVL1;FACVL1;FATP2;HsT17226;VLACS;VLCS;hFACVL1 ; |
UniProt Protein Function: | SLC27A2: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; EC 6.2.1.3; Membrane protein, integral; Ligase Chromosomal Location of Human Ortholog: 15q21.2 Cellular Component: peroxisomal membrane; integral to peroxisomal membrane; endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum lumen; integral to endoplasmic reticulum membrane Molecular Function:enzyme binding; fatty acid transporter activity; very-long-chain-fatty-acid-CoA ligase activity; phytanate-CoA ligase activity; ATP binding; receptor binding; long-chain-fatty-acid-CoA ligase activity Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation; very-long-chain fatty acid catabolic process; bile acid metabolic process; cellular lipid metabolic process; long-chain fatty acid metabolic process; fatty acid alpha-oxidation |
NCBI Summary: | The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009] |
UniProt Code: | O14975 |
NCBI GenInfo Identifier: | 308153494 |
NCBI Gene ID: | 11001 |
NCBI Accession: | O14975.2 |
UniProt Secondary Accession: | O14975,Q53FY6, Q6PF09, A8K2J7, |
UniProt Related Accession: | O14975 |
Molecular Weight: | 620 |
NCBI Full Name: | Very long-chain acyl-CoA synthetase |
NCBI Synonym Full Names: | solute carrier family 27 (fatty acid transporter), member 2 |
NCBI Official Symbol: | SLC27A2 |
NCBI Official Synonym Symbols: | VLCS; FATP2; VLACS; ACSVL1; FACVL1; hFACVL1; HsT17226 |
NCBI Protein Information: | very long-chain acyl-CoA synthetase; FATP-2; THCA-CoA ligase; fatty acid transport protein 2; long-chain-fatty-acid--CoA ligase; solute carrier family 27 member 2; very-long-chain acyl-CoA synthetase; very long-chain-fatty-acid-CoA ligase; very long-chain |
UniProt Protein Name: | Very long-chain acyl-CoA synthetase |
UniProt Synonym Protein Names: | Fatty acid transport protein 2; FATP-2; Fatty-acid-coenzyme A ligase, very long-chain 1; Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3); Solute carrier family 27 member 2; THCA-CoA ligase; Very long-chain-fatty-acid-CoA ligase |
UniProt Gene Name: | SLC27A2 |
UniProt Entry Name: | S27A2_HUMAN |