SLC27A1 Antibody (PACO18902)
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주문- SKU:
- PACO18902
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SLC27A1 Antibody (PACO18902) |
Antibody SKU: | PACO18902 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human SLC27A1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18902(SLC27A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18902(SLC27A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein involved in translocation of long-chain fatty acid, (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acid, .Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. |
Synonyms: | solute carrier family 27 (fatty acid, transporter), member 1 |
UniProt Protein Function: | SLC27A1: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Belongs to the ATP-dependent AMP-binding enzyme family. |
UniProt Protein Details: | Protein type:EC 6.2.1.-; Ligase; Lipid-binding; Membrane protein, integral; Mitochondrial; Vesicle Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: membrane; plasma membrane Molecular Function:fatty acid transporter activity Biological Process: cardiolipin biosynthetic process; long-chain fatty acid transport; phosphatidic acid biosynthetic process; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphatidylglycerol biosynthetic process; phosphatidylinositol biosynthetic process; phosphatidylserine biosynthetic process |
UniProt Code: | Q6PCB7 |
NCBI GenInfo Identifier: | 38524616 |
NCBI Gene ID: | 376497 |
NCBI Accession: | NP_940982.1 |
UniProt Secondary Accession: | Q6PCB7,A6NIH2, B7Z662, |
UniProt Related Accession: | Q6PCB7 |
Molecular Weight: | |
NCBI Full Name: | long-chain fatty acid transport protein 1 |
NCBI Synonym Full Names: | solute carrier family 27 member 1 |
NCBI Official Symbol: | SLC27A1 |
NCBI Official Synonym Symbols: | FATP; FATP1; ACSVL5; FATP-1 |
NCBI Protein Information: | long-chain fatty acid transport protein 1 |
UniProt Protein Name: | Long-chain fatty acid transport protein 1 |
UniProt Synonym Protein Names: | Solute carrier family 27 member 1 |
UniProt Gene Name: | SLC27A1 |
UniProt Entry Name: | S27A1_HUMAN |
Antibodies | ELISA Kits |
Anti-SLC27A1 Antibody (CAB12847) | Human Long-chain fatty acid transport protein 1 (SLC27A1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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