UniProt Protein Function: | SLC25A6: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Belongs to the mitochondrial carrier family. |
UniProt Protein Details: | Protein type:Transporter; Transporter, SLC family; Mitochondrial; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3 Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane; nucleus; mitochondrial inner membrane presequence translocase complex Molecular Function:protein binding; ATP:ADP antiporter activity Biological Process: ATP transport; ADP transport; cellular protein metabolic process; viral reproduction; apoptosis; active induction of host immune response by virus; virus-host interaction; energy reserve metabolic process; viral infectious cycle; regulation of insulin secretion; protein targeting to mitochondrion; transmembrane transport |
NCBI Summary: | This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013] |
UniProt Code: | P12236 |
NCBI GenInfo Identifier: | 113463 |
NCBI Gene ID: | 293 |
NCBI Accession: | P12236.4 |
UniProt Secondary Accession: | P12236,Q96C49, |
UniProt Related Accession: | P12236 |
Molecular Weight: | 298 |
NCBI Full Name: | ADP/ATP translocase 3 |
NCBI Synonym Full Names: | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
NCBI Official Symbol: | SLC25A6 |
NCBI Official Synonym Symbols: | 2; 3; ANT; AAC3; ANT3; ANT 2; ANT 3; ANT3Y |
NCBI Protein Information: | ADP/ATP translocase 3; ADP,ATP carrier protein 3; ADP/ATP translocator of liver; ADP,ATP carrier protein, liver; adenine nucleotide translocator 3; solute carrier family 25 member 6; ADP,ATP carrier protein, isoform T2 |
UniProt Protein Name: | ADP/ATP translocase 3 |
UniProt Synonym Protein Names: | ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6ADP/ATP translocase 3, N-terminally processed |
Protein Family: | ADP/ATP translocase |
UniProt Gene Name: | SLC25A6 |
UniProt Entry Name: | ADT3_HUMAN |