SLC25A12 Antibody (PACO55010)
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주문- SKU:
- PACO55010
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SLC25A12 Antibody (PACO55010) |
Antibody SKU: | PACO55010 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Rat, Mouse |
Immunogen: | Recombinant Human Calcium-binding mitochondrial carrier protein Aralar1 protein (202-317AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO55010 at dilution of 1:100. | |
Western Blot. Positive WB detected in: HEK293 whole cell lysate, Rat heart tissue, Rat kidney tissue, Mouse kidney tissue, Mouse heart tissue. All lanes: SLC25A12 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 75, 63 kDa. Observed band size: 75 kDa. | |
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO55010 at dilution of 1:100. |
Background: | Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. |
Synonyms: | Calcium-binding mitochondrial carrier protein Aralar1 (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12), SLC25A12, ARALAR1 |
UniProt Protein Function: | SLC25A12: Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. Defects in SLC25A12 are the cause of global cerebral hypomyelination (GCHM). A disorder with onset in infancy and characterized by severe psychomotor retardation, hypotonia, seizures, hypomyelination of the central nervous system, with the gray matter appearing relatively unaffected. Belongs to the mitochondrial carrier family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion Molecular Function:acidic amino acid transmembrane transporter activity; calcium ion binding; L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity Biological Process: aspartate transport; gluconeogenesis; L-glutamate transport; malate-aspartate shuttle; response to calcium ion Disease: Hypomyelination, Global Cerebral |
NCBI Summary: | This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012] |
UniProt Code: | O75746 |
NCBI GenInfo Identifier: | 206729858 |
NCBI Gene ID: | 8604 |
NCBI Accession: | O75746.2 |
UniProt Secondary Accession: | O75746,Q96AM8, B3KR64, |
UniProt Related Accession: | O75746 |
Molecular Weight: | 75kDa |
NCBI Full Name: | Calcium-binding mitochondrial carrier protein Aralar1 |
NCBI Synonym Full Names: | solute carrier family 25 member 12 |
NCBI Official Symbol: | SLC25A12 |
NCBI Official Synonym Symbols: | AGC1; ARALAR; EIEE39 |
NCBI Protein Information: | calcium-binding mitochondrial carrier protein Aralar1 |
UniProt Protein Name: | Calcium-binding mitochondrial carrier protein Aralar1 |
UniProt Synonym Protein Names: | Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12 |
UniProt Gene Name: | SLC25A12 |
Antibodies | ELISA Kits |
Anti-SLC25A12 Antibody (CAB11688) | Human SLC25A12 / Aralar1 ELISA Kit |
SLC25A12 Antibody (PACO06260) | Human Calcium-binding mitochondrial carrier protein Aralar1 (SLC25A12) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |