SLC22A2 Antibody (PACO20137)
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주문- SKU:
- PACO20137
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SLC22A2 Antibody (PACO20137) |
Antibody SKU: | PACO20137 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Rat |
Immunogen: | Synthetic peptide of human SLC22A2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20137(SLC22A2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: 293T cells, Primary antibody: PACO20137(SLC22A2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20137(SLC22A2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. |
Synonyms: | solute carrier family 22 (organic cation transporter), member 2 |
UniProt Protein Function: | SLC22A2: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: membrane; plasma membrane Molecular Function:choline transmembrane transporter activity; dopamine transmembrane transporter activity; neurotransmitter transporter activity; organic cation transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity Biological Process: body fluid secretion; choline transport; dopamine transport; multidrug transport; neurotransmitter biosynthetic process; neurotransmitter secretion; organic cation transport |
NCBI Summary: | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008] |
UniProt Code: | O15244 |
NCBI GenInfo Identifier: | 313104182 |
NCBI Gene ID: | 6582 |
NCBI Accession: | O15244.2 |
UniProt Secondary Accession: | O15244,Q5T7Q6, Q6PIQ8, Q8NG62, Q9NQB9, |
UniProt Related Accession: | O15244 |
Molecular Weight: | 26,685 Da |
NCBI Full Name: | Solute carrier family 22 member 2 |
NCBI Synonym Full Names: | solute carrier family 22 member 2 |
NCBI Official Symbol: | SLC22A2 |
NCBI Official Synonym Symbols: | OCT2 |
NCBI Protein Information: | solute carrier family 22 member 2 |
UniProt Protein Name: | Solute carrier family 22 member 2 |
UniProt Synonym Protein Names: | Organic cation transporter 2; hOCT2 |
Protein Family: | Solute carrier family |
UniProt Gene Name: | SLC22A2 |
UniProt Entry Name: | S22A2_HUMAN |