SLC1A4 Antibody (PACO18403)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO18403
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | SLC1A4 Antibody (PACO18403) |
Antibody SKU: | PACO18403 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human SLC1A4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 10+12%SDS-PAGE, Lysate: 30 μg, Lane: Human liver cancer tissue, Primary antibody: PACO18403(SLC1A4 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18403(SLC1A4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Neutral amino acid, transporter A is a protein that in humans is encoded by the SLC1A4 gene. In melanocytic cells SLC1A4 gene expression may be regulated by MITF. ASCT1 does not transport glutamate or aspartate but alanine, serine, cysteine, and threonine instead. ASCT1 transporter functions primarily as an amino acid, exchanger. Transport is associated with a chloride channel activity that is thermodynamically uncoupled from amino acid, transport. |
Synonyms: | Solute carrier family 1 (glutamate/neutral amino acid, transporter), member 4 |
UniProt Protein Function: | SLC1A4: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral Chromosomal Location of Human Ortholog: 2p15-p13 Cellular Component: centrosome; cell surface; cell soma; membrane; integral to plasma membrane; dendrite; melanosome; integral to membrane; plasma membrane; intermediate filament; microtubule organizing center Molecular Function:L-serine transmembrane transporter activity; chloride channel activity; L-threonine transmembrane transporter activity; L-proline transmembrane transporter activity; L-alanine transmembrane transporter activity; L-glutamine transmembrane transporter activity; L-cystine transmembrane transporter activity; sodium:dicarboxylate symporter activity Biological Process: synaptic transmission, glutamatergic; threonine transport; L-cystine transport; chloride transport; L-serine transport; L-alanine transport; dicarboxylic acid transport; amino acid transport; ion transport; cognition; proline transport; glutamine transport; transmembrane transport |
NCBI Summary: | The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. [provided by RefSeq, Jan 2017] |
UniProt Code: | P43007 |
NCBI GenInfo Identifier: | 1173365 |
NCBI Gene ID: | 6509 |
NCBI Accession: | P43007.1 |
UniProt Related Accession: | P43007 |
Molecular Weight: | ~56kDa |
NCBI Full Name: | Neutral amino acid transporter A |
NCBI Synonym Full Names: | solute carrier family 1 member 4 |
NCBI Official Symbol: | SLC1A4 |
NCBI Official Synonym Symbols: | SATT; ASCT1; SPATCCM |
NCBI Protein Information: | neutral amino acid transporter A |
UniProt Protein Name: | Neutral amino acid transporter A |
UniProt Synonym Protein Names: | Alanine/serine/cysteine/threonine transporter 1; ASCT-1; SATT; Solute carrier family 1 member 4 |
Protein Family: | Neutral amino acid transporter |
UniProt Gene Name: | SLC1A4 |
UniProt Entry Name: | SATT_HUMAN |