SLC12A5 Antibody (PACO13615)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO13615
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SLC12A5 Antibody (PACO13615) |
Antibody SKU: | PACO13615 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human SLC12A5-Specific |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | solute carrier family 12 (potassium-chloride transporter), member 5;SLC12A5;KCC2;KIAA1176 ; |
UniProt Protein Function: | KCC2: Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons. Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1. Brain specific. Detected in neuronal cells. Inhibited by WNK3. Belongs to the SLC12A transporter family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: cell soma; integral to plasma membrane; integral to membrane; plasma membrane; dendritic shaft Molecular Function:protein kinase binding; potassium:chloride symporter activity Biological Process: response to drug; synaptic transmission; transport; cellular ion homeostasis; multicellular organism growth; ion transport; learning; transmembrane transport; potassium ion transport; thermosensory behavior |
NCBI Summary: | K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008] |
UniProt Code: | Q9H2X9 |
NCBI GenInfo Identifier: | 161784306 |
NCBI Gene ID: | 57468 |
NCBI Accession: | Q9H2X9.3 |
UniProt Related Accession: | Q9H2X9 |
Molecular Weight: | |
NCBI Full Name: | Solute carrier family 12 member 5 |
NCBI Synonym Full Names: | solute carrier family 12 member 5 |
NCBI Official Symbol: | SLC12A5 |
NCBI Official Synonym Symbols: | KCC2; EIG14; hKCC2; EIEE34 |
NCBI Protein Information: | solute carrier family 12 member 5 |
UniProt Protein Name: | Solute carrier family 12 member 5 |
UniProt Synonym Protein Names: | Electroneutral potassium-chloride cotransporter 2; K-Cl cotransporter 2; hKCC2; Neuronal K-Cl cotransporter |
Protein Family: | Solute carrier family |
UniProt Gene Name: | SLC12A5 |
UniProt Entry Name: | S12A5_HUMAN |