SLC10A1 Antibody (PACO18310)
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주문- SKU:
- PACO18310
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SLC10A1 Antibody (PACO18310) |
Antibody SKU: | PACO18310 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:15-1:50 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human SLC10A1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18310(SLC10A1 Antibody) at dilution 1/31, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene belongs to the sodium/bile acid, cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acid, . Two homologous transporters are involved in the reabsorption of bile acid, ; the ileal sodium/bile acid, cotransporter with an apical cell localization that absorbs bile acid, from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid, cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acid, are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. |
Synonyms: | solute carrier family 10 (sodium/bile acid, cotransporter family), member 1 |
UniProt Protein Function: | NTCP: The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter Chromosomal Location of Human Ortholog: 14q24.1 Cellular Component: integral to plasma membrane; basolateral plasma membrane; plasma membrane Molecular Function:bile acid:sodium symporter activity Biological Process: bile acid and bile salt transport; bile acid metabolic process; transport; sodium ion transport; transmembrane transport |
NCBI Summary: | The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011] |
UniProt Code: | Q14973 |
NCBI GenInfo Identifier: | 2498046 |
NCBI Gene ID: | 6554 |
NCBI Accession: | Q14973.1 |
UniProt Related Accession: | Q14973 |
Molecular Weight: | |
NCBI Full Name: | Sodium/bile acid cotransporter |
NCBI Synonym Full Names: | solute carrier family 10 member 1 |
NCBI Official Symbol: | SLC10A1 |
NCBI Official Synonym Symbols: | NTCP |
NCBI Protein Information: | sodium/bile acid cotransporter |
UniProt Protein Name: | Sodium/bile acid cotransporter |
UniProt Synonym Protein Names: | Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1 |
UniProt Gene Name: | SLC10A1 |
UniProt Entry Name: | NTCP_HUMAN |