SIRT4 Antibody (PACO20469)
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주문- SKU:
- PACO20469
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SIRT4 Antibody (PACO20469) |
Antibody SKU: | PACO20469 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human SIRT4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20469(SIRT4 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 3 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20469(SIRT4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. |
Synonyms: | sirtuin 4 |
UniProt Protein Function: | SIRT4: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down- regulates insulin secretion. Has no detectable protein deacetylase activity. Belongs to the sirtuin family. Class II subfamily. |
UniProt Protein Details: | Protein type:Tumor suppressor; Mitochondrial; Deacetylase; EC 2.4.2.-; EC 3.5.1.- Chromosomal Location of Human Ortholog: 12q Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:biotinidase activity; NAD+ ADP-ribosyltransferase activity; protein binding Biological Process: chromatin silencing; glutamine metabolic process; negative regulation of fatty acid oxidation; negative regulation of insulin secretion; positive regulation of lipid biosynthetic process; protein amino acid ADP-ribosylation; response to DNA damage stimulus |
NCBI Summary: | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y6E7 |
NCBI GenInfo Identifier: | 38258657 |
NCBI Gene ID: | 23409 |
NCBI Accession: | Q9Y6E7.1 |
UniProt Secondary Accession: | Q9Y6E7,O43346, Q32M33, |
UniProt Related Accession: | Q9Y6E7 |
Molecular Weight: | 35,188 Da |
NCBI Full Name: | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
NCBI Synonym Full Names: | sirtuin 4 |
NCBI Official Symbol: | SIRT4 |
NCBI Official Synonym Symbols: | SIR2L4 |
NCBI Protein Information: | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
UniProt Protein Name: | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
UniProt Synonym Protein Names: | NAD-dependent ADP-ribosyltransferase sirtuin-4 |
Protein Family: | NAD-dependent protein deacylase |
UniProt Gene Name: | SIRT4 |
UniProt Entry Name: | SIR4_HUMAN |
Antibodies | ELISA Kits |
Anti-SIRT4 Antibody (CAB15800) | Human NAD-dependent ADP-ribosyltransferase sirtuin-4 (SIRT4) ELISA Kit |
Anti-SIRT4 Antibody (CAB7585) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |