SIGLEC8 Antibody (PACO01979)
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주문- SKU:
- PACO01979
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SIGLEC8 Antibody |
Antibody SKU: | PACO01979 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from the Internal region of human CD329. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | SIGLEC8; SAF2; Sialic acid-binding Ig-like lectin 8; Siglec-8; CDw329; Sialoadhesin family member 2; SAF-2; CD329 |
UniProt Protein Function: | SIGLEC8: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 19q13.41 Molecular Function:protein binding; transmembrane receptor activity Biological Process: signal transduction |
NCBI Summary: | Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010] |
UniProt Code: | Q9NYZ4 |
NCBI GenInfo Identifier: | 25009268 |
NCBI Gene ID: | 27181 |
NCBI Accession: | Q9NYZ4.2 |
UniProt Secondary Accession: | Q9NYZ4,Q7Z728, |
UniProt Related Accession: | Q9NYZ4 |
Molecular Weight: | 54kDa |
NCBI Full Name: | Sialic acid-binding Ig-like lectin 8 |
NCBI Synonym Full Names: | sialic acid binding Ig like lectin 8 |
NCBI Official Symbol: | SIGLEC8 |
NCBI Official Synonym Symbols: | SAF2; SIGLEC-8; SIGLEC8L |
NCBI Protein Information: | sialic acid-binding Ig-like lectin 8 |
UniProt Protein Name: | Sialic acid-binding Ig-like lectin 8 |
UniProt Synonym Protein Names: | Sialoadhesin family member 2; SAF-2 |
Protein Family: | Sialic acid-binding Ig-like lectin |
UniProt Gene Name: | SIGLEC8 |