SESN1 Antibody (PACO23481)
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주문- SKU:
- PACO23481
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SESN1 Antibody (PACO23481) |
Antibody SKU: | PACO23481 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human SESN1. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from rat muscle cells, using SESN1 antibody. | |
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SESN1 antibody. |
Background: | Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth. |
Synonyms: | Sestrin-1; p53-regulated protein PA26; SESN1; |
UniProt Protein Function: | SESN1: Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth. Belongs to the sestrin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q21 Cellular Component: nucleus Biological Process: negative regulation of cell proliferation; regulation of protein kinase B signaling cascade; cell cycle arrest; response to DNA damage stimulus |
NCBI Summary: | This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q9Y6P5 |
NCBI GenInfo Identifier: | 13633953 |
NCBI Gene ID: | 27244 |
NCBI Accession: | Q9Y6P5.2 |
UniProt Secondary Accession: | Q9Y6P5,Q2M2B7, Q5T316, Q9NV00, Q9UPD5, Q9Y6P6, |
UniProt Related Accession: | Q9Y6P5 |
Molecular Weight: | 49,624 Da |
NCBI Full Name: | Sestrin-1 |
NCBI Synonym Full Names: | sestrin 1 |
NCBI Official Symbol: | SESN1 |
NCBI Official Synonym Symbols: | PA26; SEST1 |
NCBI Protein Information: | sestrin-1; p53 activated gene 26; p53 regulated PA26 nuclear protein |
UniProt Protein Name: | Sestrin-1 |
UniProt Synonym Protein Names: | p53-regulated protein PA26 |
Protein Family: | Sestrin |
UniProt Gene Name: | SESN1 |
UniProt Entry Name: | SESN1_HUMAN |
Antibodies | ELISA Kits |
SESN1 Antibody (PACO03888) | Human SESN1 / Sestrin-1 ELISA Kit |
SESN1 Antibody (PACO12125) | Human Sestrin-1 (SESN1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |