SERPING1 Antibody (PACO49998)
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주문- SKU:
- PACO49998
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SERPING1 Antibody (PACO49998) |
Antibody SKU: | PACO49998 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Rat |
Immunogen: | Recombinant Human Plasma protease C1 inhibitor protein (23-300AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO49998 at dilution of 1:100. | |
Western Blot. Positive WB detected in: A549 whole cell lysate, MCF-7 whole cell lysate, K562 whole cell lysate, PC-3 whole cell lysate, Rat lung tissue. All lanes: SERPING1 antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 56, 50 kDa. Observed band size: 56 kDa. | |
Immunofluorescent analysis of HepG2 cells using PACO49998 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. |
Synonyms: | Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1), SERPING1, C1IN C1NH |
UniProt Protein Function: | SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11q12.1 Cellular Component: extracellular space; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; protein binding Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; complement activation, classical pathway; blood coagulation, intrinsic pathway; aging Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I |
NCBI Summary: | This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008] |
UniProt Code: | P05155 |
NCBI GenInfo Identifier: | 124096 |
NCBI Gene ID: | 710 |
NCBI Accession: | P05155.2 |
UniProt Secondary Accession: | P05155,Q16304, Q547W3, Q59EI5, Q7Z455, Q96FE0, Q9UC49 A6NMU0, A8KAI9, B2R6L5, B4E1F0, B4E1H2, |
UniProt Related Accession: | P05155 |
Molecular Weight: | |
NCBI Full Name: | Plasma protease C1 inhibitor |
NCBI Synonym Full Names: | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 |
NCBI Official Symbol: | SERPING1 |
NCBI Official Synonym Symbols: | C1IN; C1NH; HAE1; HAE2; C1INH |
NCBI Protein Information: | plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1 |
UniProt Protein Name: | Plasma protease C1 inhibitor |
UniProt Synonym Protein Names: | C1 esterase inhibitor; C1-inhibiting factor; Serpin G1 |
Protein Family: | Para-Rep |
UniProt Gene Name: | SERPING1 |
UniProt Entry Name: | IC1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |