SEPT2 Antibody (PACO22589)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO22589
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | SEPT2 Antibody (PACO22589) |
Antibody SKU: | PACO22589 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human SEPT2. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from Jurkat cells and MCF-7 cells, using SEPT2 antibody. |
Background: | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. |
Synonyms: | Protein NEDD5; Septin-2; Neural precursor cell expressed developmentally down-regulated protein 5; DIFF6; KIAA0158 |
UniProt Protein Function: | SEPT2: a member of the septin family of proteins. May be involved in the process of cytokinesis. Accumulates near the contractile ring from anaphase through telophase, and finally condenses into the midbody. In interphase and postmitotic cells, localized to fibrous or granular structures, depending on the growth state of the cell. |
UniProt Protein Details: | Protein type:Cytoskeletal; Hydrolase; Cell development/differentiation; Motility/polarity/chemotaxis; Cell cycle regulation Chromosomal Location of Human Ortholog: 2q37 Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleolus; exocyst; synapse; spindle; midbody; cell cortex; nucleus; actin cytoskeleton; cleavage furrow Molecular Function:protein binding; GTP binding; protein complex scaffold; enzyme regulator activity Biological Process: mitosis; smoothened signaling pathway; regulation of protein localization; regulation of catalytic activity; cell division; cilium biogenesis; regulation of L-glutamate transport; neurite development |
UniProt Code: | Q15019 |
NCBI GenInfo Identifier: | 2500769 |
NCBI Gene ID: | 4735 |
NCBI Accession: | Q15019.1 |
UniProt Secondary Accession: | Q15019,Q14132, Q53QU3, Q8IUK9, Q96CB0, B4DGE8, |
UniProt Related Accession: | Q15019 |
Molecular Weight: | 361 |
NCBI Full Name: | Septin-2 |
NCBI Synonym Full Names: | septin 2 |
NCBI Official Symbol: | SEPT2 |
NCBI Official Synonym Symbols: | DIFF6; NEDD5; NEDD-5; Pnutl3; hNedd5 |
NCBI Protein Information: | septin-2; neural precursor cell expressed, developmentally down-regulated 5; neural precursor cell expressed developmentally down-regulated protein 5 |
UniProt Protein Name: | Septin-2 |
UniProt Synonym Protein Names: | Neural precursor cell expressed developmentally down-regulated protein 5; NEDD-5 |
UniProt Gene Name: | SEPT2 |
UniProt Entry Name: | SEPT2_HUMAN |