SENP1 Antibody (PACO48782)
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주문- SKU:
- PACO48782
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SENP1 Antibody (PACO48782) |
Antibody SKU: | PACO48782 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Sentrin-specific protease 1 protein (63-214AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Hela whole cell lysate, HL60 whole cell lysate, Jurkat whole cell lysate, Mouse heart tissue, Mouse brain tissue, Mouse spleen tissue, Mouse stomach tissue, Mouse skeletal muscle tissue. All lanes: SENP1 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 74 kDa. Observed band size: 74, 50 kDa.. | |
Immunofluorescent analysis of Hela cells using PACO48782 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO48782 at dilution of 1:100. |
Background: | Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1. |
Synonyms: | Sentrin-specific protease 1 (EC 3.4.22) (Sentrin/SUMO-specific protease SENP1), SENP1 |
UniProt Protein Function: | SENP1: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.22.68; Protease; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 12q13.1 Cellular Component: focal adhesion; nuclear membrane; nucleoplasm; nucleus Molecular Function:endopeptidase activity; protein binding; SUMO-specific protease activity Biological Process: caspase activation; positive regulation of transcription from RNA polymerase II promoter; protein desumoylation; protein sumoylation; proteolysis |
NCBI Summary: | This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] |
UniProt Code: | Q9P0U3 |
NCBI GenInfo Identifier: | 215273882 |
NCBI Gene ID: | 29843 |
NCBI Accession: | Q9P0U3.2 |
UniProt Secondary Accession: | Q9P0U3,Q86XC8, A8K7P5, |
UniProt Related Accession: | Q9P0U3 |
Molecular Weight: | 73,351 Da |
NCBI Full Name: | Sentrin-specific protease 1 |
NCBI Synonym Full Names: | SUMO1/sentrin specific peptidase 1 |
NCBI Official Symbol: | SENP1 |
NCBI Official Synonym Symbols: | SuPr-2 |
NCBI Protein Information: | sentrin-specific protease 1 |
UniProt Protein Name: | Sentrin-specific protease 1 |
UniProt Synonym Protein Names: | Sentrin/SUMO-specific protease SENP1 |
Protein Family: | Sentrin-specific protease |
UniProt Gene Name: | SENP1 |
UniProt Entry Name: | SENP1_HUMAN |
Antibodies | ELISA Kits |
Anti-SENP1 Antibody (CAB13086) | SENP1 Colorimetric Cell-Based ELISA Kit |
Anti-SENP1 Antibody (CAB4460) | |
SENP1 Antibody (PACO01480) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |