SEMA3C Antibody (PACO59365)
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주문- SKU:
- PACO59365
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SEMA3C Antibody (PACO59365) |
Antibody SKU: | PACO59365 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Semaphorin-3C protein (292-396AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO59365 diluted at 1:500 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). |
Synonyms: | Semaphorin-3C (Semaphorin-E) (Sema E), SEMA3C, SEMAE |
UniProt Protein Function: | SEMA3C: a secreted protein that may be involved in cell survival mechanisms. Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain. Binds with high affinity to the receptor NRP2. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 7q21-q31 Cellular Component: extracellular space; membrane Molecular Function:receptor activity; semaphorin receptor binding Biological Process: neural tube development; response to drug; axon guidance; limb bud formation; somitogenesis; blood vessel remodeling; immune response; neural crest cell migration; post-embryonic development |
NCBI Summary: | This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017] |
UniProt Code: | Q99985 |
NCBI GenInfo Identifier: | 8134685 |
NCBI Gene ID: | 10512 |
NCBI Accession: | Q99985.2 |
UniProt Related Accession: | Q99985 |
Molecular Weight: | ~ 85kDa |
NCBI Full Name: | Semaphorin-3C |
NCBI Synonym Full Names: | semaphorin 3C |
NCBI Official Symbol: | SEMA3C |
NCBI Official Synonym Symbols: | SemE; SEMAE |
NCBI Protein Information: | semaphorin-3C |
UniProt Protein Name: | Semaphorin-3C |
UniProt Synonym Protein Names: | Semaphorin-E; Sema E |
Protein Family: | Semaphorin |
UniProt Gene Name: | SEMA3C |
UniProt Entry Name: | SEM3C_HUMAN |
Antibodies | ELISA Kits |
Anti-SEMA3C Antibody (CAB15386) | Human Semaphorin-3C (SEMA3C) ELISA Kit |
SEMA3C Antibody (PACO03345) | |
SEMA3C Antibody (PACO12092) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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