UniProt Protein Function: | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. |
NCBI Summary: | The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
UniProt Code: | O94979 |
NCBI GenInfo Identifier: | 1207836306 |
NCBI Gene ID: | 22872 |
NCBI Accession: | OWK13809.1 |
UniProt Secondary Accession: | O94979,Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9 Q86TJ0, B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, |
UniProt Related Accession: | O94979 |
Molecular Weight: | 133kDa |
NCBI Full Name: | SEC31A, partial |
NCBI Synonym Full Names: | SEC31 homolog A, COPII coat complex component |
NCBI Official Symbol: | SEC31A |
NCBI Official Synonym Symbols: | ABP125; ABP130; HSPC275; HSPC334; SEC31L1 |
NCBI Protein Information: | protein transport protein Sec31A |
UniProt Protein Name: | Protein transport protein Sec31A |
UniProt Synonym Protein Names: | ABP125; ABP130; SEC31-like protein 1; SEC31-related protein A; Web1-like protein |
Protein Family: | Protein transport protein |
UniProt Gene Name: | SEC31A |