SCN2A Antibody (PACO18871)
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주문- SKU:
- PACO18871
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SCN2A Antibody (PACO18871) |
Antibody SKU: | PACO18871 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Rat |
Immunogen: | Synthetic peptide of human SCN2A |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18871(SCN2A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large α subunit with 24 transmembrane domains and one or more regulatory β subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel α subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. |
Synonyms: | sodium channel, voltage-gated, type II, α subunit |
UniProt Protein Function: | SCN2A: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Defects in SCN2A are the cause of seizures, benign familial infantile type 3 (BFIS3). An autosomal dominant disorder in which afebrile seizures occur in clusters during the first year of life, without neurologic sequelae. Defects in SCN2A are the cause of epileptic encephalopathy early infantile type 11 (EIEE11). EIEE11 is an autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 2q24.3 Cellular Component: axon; integral to plasma membrane; intrinsic to plasma membrane Molecular Function:voltage-gated sodium channel activity Biological Process: generation of action potential; myelination; sodium ion transport Disease: Epileptic Encephalopathy, Early Infantile, 11; Seizures, Benign Familial Infantile, 3 |
NCBI Summary: | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] |
UniProt Code: | Q99250 |
NCBI GenInfo Identifier: | 25014053 |
NCBI Gene ID: | 6326 |
NCBI Accession: | Q99250.3 |
UniProt Secondary Accession: | Q99250,Q14472, Q53T77, Q9BZC9, Q9BZD0, A6NC14, A6NIQ5 |
UniProt Related Accession: | Q99250 |
Molecular Weight: | 228kDa |
NCBI Full Name: | Sodium channel protein type 2 subunit alpha |
NCBI Synonym Full Names: | sodium voltage-gated channel alpha subunit 2 |
NCBI Official Symbol: | SCN2A |
NCBI Official Synonym Symbols: | HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2 |
NCBI Protein Information: | sodium channel protein type 2 subunit alpha |
UniProt Protein Name: | Sodium channel protein type 2 subunit alpha |
UniProt Synonym Protein Names: | HBSC II; Sodium channel protein brain II subunit alpha; Sodium channel protein type II subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.2 |
Protein Family: | Sodium channel protein |
UniProt Gene Name: | SCN2A |