RXFP1 Antibody (PACO59421)
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주문- SKU:
- PACO59421
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RXFP1 Antibody (PACO59421) |
Antibody SKU: | PACO59421 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Relaxin receptor 1 protein (17-151AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescence staining of Hela cells with PACO59421 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. |
Synonyms: | Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1), RXFP1, LGR7 |
UniProt Protein Function: | RXFP1: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. Belongs to the G-protein coupled receptor 1 family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 4q32.1 Cellular Component: plasma membrane; integral to membrane Molecular Function:G-protein coupled receptor activity; protein binding; metal ion binding Biological Process: G-protein coupled receptor protein signaling pathway |
NCBI Summary: | This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q9HBX9 |
NCBI GenInfo Identifier: | 166209887 |
NCBI Gene ID: | 59350 |
NCBI Accession: | Q9HBX9.2 |
UniProt Secondary Accession: | Q9HBX9,Q2M215, Q3KU24, Q3KU25, Q3KU26, B4DHD1, B4DTV2 |
UniProt Related Accession: | Q9HBX9 |
Molecular Weight: | 757 |
NCBI Full Name: | Relaxin receptor 1 |
NCBI Synonym Full Names: | relaxin/insulin-like family peptide receptor 1 |
NCBI Official Symbol: | RXFP1 |
NCBI Official Synonym Symbols: | LGR7; RXFPR1 |
NCBI Protein Information: | relaxin receptor 1; leucine-rich repeat-containing G protein-coupled receptor 7 |
UniProt Protein Name: | Relaxin receptor 1 |
UniProt Synonym Protein Names: | Leucine-rich repeat-containing G-protein coupled receptor 7; Relaxin family peptide receptor 1 |
Protein Family: | Relaxin receptor |
UniProt Gene Name: | RXFP1 |
UniProt Entry Name: | RXFP1_HUMAN |
Antibodies | ELISA Kits |
Anti-RXFP1 Antibody (CAB7127) | Human GPCR LGR7 / Relaxin R1 ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |