RSPO3 Antibody (PACO42134)
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주문- SKU:
- PACO42134
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RSPO3 Antibody (PACO42134) |
Antibody SKU: | PACO42134 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human R-spondin-3 protein (22-272AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human lung cancer using PACO42134 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO42134 at dilution of 1:100. |
Background: | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-β pathway. |
Synonyms: | R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2), RSPO3, PWTSR THSD2 |
UniProt Protein Function: | R-spondin-3: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Belongs to the R-spondin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell development/differentiation; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 6q22.33 Cellular Component: extracellular space; extracellular region Molecular Function:heparin binding; G-protein-coupled receptor binding; frizzled binding; receptor binding Biological Process: Wnt receptor signaling pathway through beta-catenin |
NCBI Summary: | This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q9BXY4 |
NCBI GenInfo Identifier: | 74752442 |
NCBI Gene ID: | 84870 |
NCBI Accession: | Q9BXY4.1 |
UniProt Secondary Accession: | Q9BXY4,Q5VTV4, Q96K87, B2RC27, |
UniProt Related Accession: | Q9BXY4 |
Molecular Weight: | 33,233 Da |
NCBI Full Name: | R-spondin-3 |
NCBI Synonym Full Names: | R-spondin 3 |
NCBI Official Symbol: | RSPO3 |
NCBI Official Synonym Symbols: | PWTSR; THSD2; CRISTIN1 |
NCBI Protein Information: | R-spondin-3; R-spondin 3 homolog; roof plate-specific spondin-3; protein with TSP type-1 repeat; thrombospondin, type I, domain containing 2; thrombospondin type-1 domain-containing protein 2 |
UniProt Protein Name: | R-spondin-3 |
UniProt Synonym Protein Names: | Protein with TSP type-1 repeat; hPWTSR; Roof plate-specific spondin-3; hRspo3; Thrombospondin type-1 domain-containing protein 2 |
Protein Family: | R-spondin |
UniProt Gene Name: | RSPO3 |
UniProt Entry Name: | RSPO3_HUMAN |