RPN2 Antibody (PACO44848)
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주문- SKU:
- PACO44848
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | RPN2 Antibody (PACO44848) |
Antibody SKU: | PACO44848 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 protein (360-540AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: RPN2 antibody at 1.91µg/ml. Lane 1: NIH/3T3 whole cell lysate. Lane 2: 293T whole cell lysate. Lane 3: Hela whole cell lysate. Lane 4: Human placenta tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 70, 68 kDa. Observed band size: 70 kDa.. | |
Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO44848 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO44848 at dilution of 1:100. |
Background: | Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. |
Synonyms: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2), RPN2 |
UniProt Protein Function: | RPN2: Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Belongs to the SWP1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.4.99.18; Transferase; Membrane protein, multi-pass; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis Chromosomal Location of Human Ortholog: 20q12-q13.1 Cellular Component: endoplasmic reticulum membrane; rough endoplasmic reticulum; membrane; endoplasmic reticulum; oligosaccharyl transferase complex; integral to membrane; nucleus Molecular Function:dolichyl-diphosphooligosaccharide-protein glycotransferase activity; ribosome binding Biological Process: response to drug; SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; protein modification process; gene expression; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; aging |
NCBI Summary: | This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
UniProt Code: | P04844 |
NCBI GenInfo Identifier: | 9297108 |
NCBI Gene ID: | 6185 |
NCBI Accession: | P04844.3 |
UniProt Secondary Accession: | P04844,Q5JYR6, Q6IBA5, Q96E21, Q9BUQ3, Q9UBE1, |
UniProt Related Accession: | P04844 |
Molecular Weight: | 67,723 Da |
NCBI Full Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 |
NCBI Synonym Full Names: | ribophorin II |
NCBI Official Symbol: | RPN2 |
NCBI Official Synonym Symbols: | SWP1; RPNII; RIBIIR; RPN-II |
NCBI Protein Information: | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; ribophorin-2; oligosaccharyltransferase complex subunit (non-catalytic); dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit |
UniProt Protein Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 |
UniProt Synonym Protein Names: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit; RIBIIR; Ribophorin II; RPN-II; Ribophorin-2 |
Protein Family: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase |
UniProt Gene Name: | RPN2 |
UniProt Entry Name: | RPN2_HUMAN |