RPN1 Antibody (PACO15612)
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주문- SKU:
- PACO15612
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RPN1 Antibody (PACO15612) |
Antibody SKU: | PACO15612 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human RPN1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO15612(RPN1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Hela cells, A549 cells, MCF7 cells, human liver cancer tissue, Human lung cancer tissue, Primary antibody: PACO15612(RPN1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15612(RPN1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. |
Synonyms: | ribophorin I |
UniProt Protein Function: | RPN1: Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Belongs to the OST1 family. |
UniProt Protein Details: | Protein type:EC 2.4.99.18; Glycan Metabolism - N-glycan biosynthesis; Transferase; Membrane protein, integral Chromosomal Location of Human Ortholog: 3q21.3 Cellular Component: endoplasmic reticulum membrane; membrane; rough endoplasmic reticulum; oligosaccharyl transferase complex; integral to membrane; melanosome Molecular Function:protein binding; dolichyl-diphosphooligosaccharide-protein glycotransferase activity Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; protein modification process; protein amino acid N-linked glycosylation via asparagine; gene expression; post-translational protein modification |
NCBI Summary: | This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008] |
UniProt Code: | P04843 |
NCBI GenInfo Identifier: | 132559 |
NCBI Gene ID: | 6184 |
NCBI Accession: | P04843.1 |
UniProt Secondary Accession: | P04843,Q68DT1, B2R5Z0, D3DNB6, |
UniProt Related Accession: | P04843 |
Molecular Weight: | 607 |
NCBI Full Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 |
NCBI Synonym Full Names: | ribophorin I |
NCBI Official Symbol: | RPN1 |
NCBI Official Synonym Symbols: | OST1; RBPH1 |
NCBI Protein Information: | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; RPN-I; ribophorin-1; oligosaccharyltransferase 1 homolog; oligosaccharyltransferase complex subunit (non-catalytic); dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit |
UniProt Protein Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 |
UniProt Synonym Protein Names: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit; Ribophorin I; RPN-I; Ribophorin-1 |
Protein Family: | 26S proteasome regulatory |
UniProt Gene Name: | RPN1 |
UniProt Entry Name: | RPN1_HUMAN |