RNF41 Antibody (PACO45204)
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주문- SKU:
- PACO45204
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | RNF41 Antibody (PACO45204) |
Antibody SKU: | PACO45204 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human E3 ubiquitin-protein ligase NRDP1 protein (1-317AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: RNF41 antibody at 5.55 µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 36, 28 kDa. Observed band size: 36, 50, 55 kDa.. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO45204 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO45204 at dilution of 1:100. |
Background: | Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. |
Synonyms: | E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1), RNF41, FLRF NRDP1 |
UniProt Protein Function: | RNF41: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL- 3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19Chromosomal Location of Human Ortholog: 12q13.13Cellular Component: cytosolMolecular Function: protein binding; Ral GTPase binding; ubiquitin-protein ligase activityBiological Process: negative regulation of cell migration; negative regulation of cell proliferation; proteasomal protein catabolic process; protein autoubiquitination; protein polyubiquitination; regulation of MAPKKK cascade; regulation of protein kinase B signaling cascade |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011] |
UniProt Code: | Q9H4P4 |
NCBI GenInfo Identifier: | 88909120 |
NCBI Gene ID: | 10193 |
NCBI Accession: | Q9H4P4.2 |
UniProt Secondary Accession: | Q9H4P4,O75598, A6NFW0, B2RBT8 |
UniProt Related Accession: | Q9H4P4 |
Molecular Weight: | 27,965 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase NRDP1 |
NCBI Synonym Full Names: | ring finger protein 41 |
NCBI Official Symbol: | RNF41 |
NCBI Official Synonym Symbols: | FLRF; NRDP1; SBBI03 |
NCBI Protein Information: | E3 ubiquitin-protein ligase NRDP1 |
UniProt Protein Name: | E3 ubiquitin-protein ligase NRDP1 |
UniProt Synonym Protein Names: | RING finger protein 41 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RNF41 |
UniProt Entry Name: | RNF41_HUMAN |